Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

Abstract

Giving consent is an ethical cornerstone of modern clinical research. However, consent practices have been problematic for decades: consent forms are too long while comprehension of consent documents is consistently poor. These issues are compounded for acute stroke clinical trials, as patients are often incapacitated, and treatment decisions must be made very quickly. Moreover, clinical trials are becoming more complicated: platform adaptive trials offer the promise of faster results, but also mean that patients may be randomized to receive multiple interventions in succession. The multi-faCtorial, mulTi-arm, multi-staGe, randomised, gLOBal Adaptive pLatform trial for stroke (ACT-GLOBAL), the world's first adaptive platform trial for acute stroke, exemplifies many of these opportunities and challenges.

In this presentation, we will explore the complexities of giving consent for acute stroke trials, and review the recent consent innovations adopted by the stroke trial community. We will then introduce the COMPACT research program, which seeks to explore consent modernization for platform adaptive trials in stroke.

 

Zoom link https://medsci.zoom.us/j/93440952102