Ethox Seminar - Consent Modernization for Platform Adaptive Trials: The Example of the ACT-GLOBAL Trial
Michel Shamy, Associate Professor, University of Ottawa, Attending Neurologist, The Ottawa Hospital, and Andrew Markus Visiting Scholar, Ethox Centre
Thursday, 20 March 2025, 10.30am to 12pm
This will be a hybrid seminar in the Big Data Institute, Lower Ground Seminar Room 1, or on Zoom (see joining link below)
Abstract
Giving consent is an ethical cornerstone of modern clinical research. However, consent practices have been problematic for decades: consent forms are too long while comprehension of consent documents is consistently poor. These issues are compounded for acute stroke clinical trials, as patients are often incapacitated, and treatment decisions must be made very quickly. Moreover, clinical trials are becoming more complicated: platform adaptive trials offer the promise of faster results, but also mean that patients may be randomized to receive multiple interventions in succession. The multi-faCtorial, mulTi-arm, multi-staGe, randomised, gLOBal Adaptive pLatform trial for stroke (ACT-GLOBAL), the world's first adaptive platform trial for acute stroke, exemplifies many of these opportunities and challenges.
In this presentation, we will explore the complexities of giving consent for acute stroke trials, and review the recent consent innovations adopted by the stroke trial community. We will then introduce the COMPACT research program, which seeks to explore consent modernization for platform adaptive trials in stroke.
Zoom link https://medsci.zoom.us/j/93440952102