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MalariaGEN is a partnership of researchers in 21 countries who are using genomic epidemiology to understand how protective immunity in malaria works, which is a fundamental problem in malaria vaccine development. This work is jointly funded by the Wellcome Trust and by the Bill and Melinda Gates Foundation, through the Foundation for the National Institutes of Health, as part of the Grand Challenges in Global Health Initiative. The Ethox Centre leads the MalariaGEN ethics programme.