Wilms tumor is the most common renal malignancy of childhood. To identify common variants that confer susceptibility to Wilms tumor, we conducted a genome-wide association study in 757 individuals with Wilms tumor (cases) and 1,879 controls. We evaluated ten SNPs in regions significantly associated at P < 5 × 10(-5) in two independent replication series from the UK (769 cases and 2,814 controls) and the United States (719 cases and 1,037 controls). We identified clear significant associations at 2p24 (rs3755132, P = 1.03 × 10(-14); rs807624, P = 1.32 × 10(-14)) and 11q14 (rs790356, P = 4.25 × 10(-15)). Both regions contain genes that are plausibly related to Wilms tumorigenesis. We also identified candidate association signals at 5q14, 22q12 and Xp22.

Original publication

DOI

10.1038/ng.2251

Type

Journal article

Journal

Nat Genet

Publication Date

29/04/2012

Volume

44

Pages

681 - 684

Keywords

Chromosomes, Human, Pair 11, Chromosomes, Human, Pair 2, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Kidney Neoplasms, Polymorphism, Single Nucleotide, Wilms Tumor